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The Systems Biology Consortium for Infectious Diseases is a group of interdisciplinary scientists that bridge disparate scientific disciplines including microbiology, immunology, infectious diseases, microbiome, mathematics, physics, bioinformatics, computational biology, machine learning, statistical methods, and mathematical modeling. These teams integrate large-scale experimental biological and clinical data across temporal and spatial scales. Scientists iteratively test and validate hypotheses to gain insight into the overall complexity of the biological, biochemical, and biophysical molecular processes within microbial organisms as well as their interaction with the host. The research findings drive innovation and discovery, with the goal of developing novel therapeutic and diagnostic strategies, and predictive signatures of disease to alleviate infectious disease burden and provide solutions to complex public health challenges and disease outbreaks.

Currently funded centers
SARS-CoV adaptations through a Systems Biology Lens (SYBIL)
PI: Adolfo Garcia-Sastre, Icahn School of Medicine at Mount Sinai

Successful Clinical Response in Pneumonia Therapy (SCRIPT) Systems Biology Center
PI: Richard Wunderink, Northwestern University at Chicago

Center for Viral Systems Biology (CViSB)
PI: Kristian Andersen, Scripps Research

Systems Epigenomics of Persistent Bloodstream Infection
PI: Michael Yeaman, University of California, Los Angeles

Host Pathogen Mapping Initiative (HPMI)
PI: Nevan Krogan, University of California, San Francisco

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What are the immunological, genetic, microbial and physiological attributes that play essential roles in determining outcomes from viral infections? The mission of the Center for Viral Systems Biology (CViSB; pronounced “SEE-VIZ-bee”) is to identify such factors and elucidate the molecular and immunological networks that determine outcomes of human disease. We hope that via this research we will be able to provide a deep system-level understanding of the virus and human determinants of clinical outcome to discover predictive markers of disease, and guide future therapies.

What are the immunological, genetic, microbial and physiological attributes that play essential roles in determining outcomes from viral infections? The mission of the Center for Viral Systems Biology (CViSB; pronounced “SEE-VIZ-bee”) is to identify such factors and elucidate the molecular and immunological networks that determine outcomes of human disease. We hope that via this research we will be able to provide a deep system-level understanding of the virus and human determinants of clinical outcome to discover predictive markers of disease, and guide future therapies.

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